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. Author manuscript; available in PMC: 2010 Mar 10.
Published in final edited form as: Dev Biol. 2005 Sep 15;285(2):316–329. doi: 10.1016/j.ydbio.2005.06.038

Fig. 2.

Fig. 2

Structural homology between Nephrin and Podocin of man and zebrafish. SMART (Simple Modular Architecture Research Tool) was used for determination of structural similarity between the human and zebrafish homologs. Nephrin (A,B) is a type-1 integral membrane protein, with several immunoglobuline-like domains and fibronectin domain close to the transmembrane domain while podocin (C,D) has a hairpin shape with a prohibitin homology domain. FN3, Fibronectin type 3 domain; IG, Immunoglobulin-like domain; IGc2, Immunoglobulin C-2 type domain; PHB, prohibitin homology domain; SP, signal peptide; TM, transmembrane domain. Amino acid alignments for nephrin and podocin are shown in Supplementary Fig. 1.