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Involvement of Rho GTPases in NT3-induced cell migration and JNK activation. Rat Schwann cells (A and C) and Cos-7 cells transfected with TrkC (B) or TrkC and HA-JNK (D) were pretreated with Toxin B. (A and B) After incubation with NT3, the migrating cells in the Boyden chambers were stained and counted. (C and D) The activity of endogenous JNK or HA-JNK was measured 30 min after stimulation with NT3. Data were evaluated by using Student's t test. *, P < 0.01.
