FIGURE 2.

Effects of als and igfbp-3 gene inactivation on bone marrow-derived adipocyte differentiation. Bone marrow cells were isolated from 8–10-week-old control (n = 5), LID (n = 5), ALSKO (n = 4), and BP3KO (n = 4) mice and cultured in adipogenic media, as described under “Experimental Procedures.” Adipocytes were detected by Oil-Red-O staining 14 days following adipogenesis induction and are presented as number of adipocytes per well. Data are expressed as mean ± S.E. *, p < 0.05 versus control.