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Sequence and structure of the α-spectrin EF-domain. Amino acids that are 70% identical among the α-spectrin family members listed are shaded. The Ca2+-sensitive EF-hands (EF1 and EF2) are on top, the Ca2+-insensitive EF-domain (EF34) is on the bottom. The predicted α-helices in human α-spectrin 1 are marked (h), as are the actual α-helices in chicken α-spectrin-2 (9).
