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HBP1 inhibits c-Myc activity by multiple mechanisms. HBP1 binds c-Myc and prevents its interaction with DNA thereby preventing activation of c-Myc target genes. Additionally, HBP1 can bind TCF4 and prevent its binding to promoters of target genes including c-MYC (23). Therefore, HBP1 can inhibit both the activity and expression of c-Myc.
