Fig. 4.

A physiological concentration (10 nM) of THDOC reduces the fEPSP slope when δ-subunits are present. (A and D) Time vs. average fEPSP slope evoked by W = 60 μs (EPSP₆₀). Data were pooled and normalized to the average fEPSP slope evoked during first 10 min (n = 4 slices). (B and E) fEPSPs evoked during stimulus response curves before (Left) and after (Right)10nM THDOC (20 min). The dashed line compares the two EPSP₁₂₀ responses (bold, evoked by a W closest to the fitted W₅₀). (C and F) Stimulus–response curves after 20 min of 10 nM THDOC (•) in the dentate gyrus (C) or the striatum radiatum of CA1 (F). Data (±SEM) are normalized to the slope of the EPSP₂₄₀ (evoked by W = 240 μs) under control conditions (○). Lines represent the Boltzman equation fitted to the means.