FIGURE 8.

Model of Fgf9 regulation of Ptgs2 expression in cMSCs. Colonic MSCs express CD29, CD34, CD44, CD54, CD90, CD105, CD106, Sca-1, and Ptgs2. When Fgf9 is present, it signals through Fgfr1c and/or Fgfr2c on the cell surface. Transduction of this signal via ERK phosphorylation and activation results in an increase in CUGbp2 protein. This protein in turn binds to Ptgs2 mRNA and stabilizes the message. In the absence of Fgf9, ERK phosphorylation is decreased, resulting in decreased CUGbp2 protein quantity and loss of Ptgs2 mRNA stabilization.