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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Trends Immunol. 2009 Jul 28;30(8):392–400. doi: 10.1016/j.it.2009.07.001

Figure 1.

Figure 1

Domain structure of SOCS1 and SOCS3. SOCS1 and SOCS3 proteins are comprised of an N-terminal variable region, a 12-amino acid (aa) kinase-inhibitory region (KIR), a 12-aa extended SH2 subdomain (ESS), a classical SH2 domain and a C-terminal SOCS box. Four residues of the KIR (F56, F59, D64 and Y65) are crucial for inhibiting the kinase activity of JAK2. The I68 and L75 residues of the ESS region are crucial for interaction with pY1007 of JAK2. The SOCS box associates with elongins C and B, which interact with components of the ubiquitin-ligase machinery, to target SOCS1, SOCS3 and associated proteins for degradation by the proteosome.