Table 2.
Mechanism of SOCS1 and SOCS3 expression in CNS cells
| Cell type | SOCS1 Inducer | Pathway | SOCS3 Inducer | Pathway |
|---|---|---|---|---|
| Microglia | IFN-γ | JAK/STAT | IFN-γ | JAK/STAT |
| IFN-β | JAK/STAT1 | IFN-β | JAK/STAT3 | |
| LPS | ? | LPS | IL-10-JAK/STAT3, MAPK | |
| IL-4 | JAK/STAT | IL-10 | JAK/STAT3 | |
| HIV-1 Tat | NF-κB | |||
| Thrombin | PKC-™ | |||
| Astrocytes | 15d-PGJ2 | Non-JAK/STAT | 15d-PGJ2 | Non-JAK/STAT |
| Rosiglitazone | Non-JAK/STAT | Rosiglitazone | Non-JAK/STAT | |
| IFN-γ | JAK/STAT | IFN-γ | JAK/STAT | |
| IFN-β | JAK/STAT | IFN-β | JAK/STAT | |
| OSM | JAK/STAT1 | OSM | JAK/STAT3, MAPK | |
| CNTF | ? | |||
| Neurons | IFN-γ | JAK/STAT | IGF-1 | JAK/STAT3 |
| IL-6 | JAK/STAT | |||
| OSM | JAK/STAT | |||
| LPS | ? | |||
| Oligodendrocytes | IFN-γ | JAK/STAT | LIF | JAK/STAT |
| Macrophages | IFN-γ | JAK/STAT | IFN-γ | JAK/STAT |
| IFN-β | JAK/STAT | IFN-β | JAK/STAT | |
| LPS | ? | LPS | IL-10-JAK/STAT, MAPK | |
| IL-10 | JAK/STAT3 | IL-10 | JAK/STAT3 | |
| CpG | MAPK | CpG | MAPK | |
| IL-4 | JAK/STAT6 | HIV-1 Tat | NF-κB | |
| FMLP | Non-JAK/STAT | IL-6 | JAK/STAT3 | |
| IL-8 | Non-JAK/STAT | TNF-α | MAPK (RNA stabilization) | |
| IL-21 | ? | |||
| Dendritic cells | CpG | MAPK | CpG | MAPK |
| IL-21 | ? | IL-21 | ? | |
| FMLP | Non-JAK/STAT | |||
| IL-8 | Non-JAK/STAT | |||
| T cells | IL-6 | JAK/STAT | IL-6 | JAK/STAT |
| IL-4 | JAK/STAT1 | IL-4 | JAK/STAT1 | |
| IL-12 | JAK/STAT | IL-12 | JAK/STAT1 | |
| IFN-γ | JAK/STAT | IFN-γ | JAK/STAT1 | |
| IFN-α | ? | IFN-α | ? | |
| Flagellin | ? |