TABLE 1:

Conserved survival and longevity hormetic inducible pathways^*

ANCIENT PATHWAY	HORMESIS
Genetic Stability/DNA Repair	Heat, Radiation,
Metabolic Control/IGF1, AMPK	Diet Restriction, Hibernation
Antioxidant	Diet Restriction, Radiation, Heat, Exercise
FOXO/AMPK	Energy Disruptors; CR, Exercise, Toxic chemicals
Heat Shock Response	Heat, Exercise
Hibernation	Cold, Hunger, Ischemia
Immunity	Infectious Agents
Regulators
Sirtuins	Diet Restriction
Ubiquitin	Exercise, Diet Restriction

^*See text for explanations and references.