Table 3.
Genes Detected by Microarray as Being Differentially Expressed in WKY Rats in Proximity to QTL for Anxiety or Despaira
| Protein encoded by gene | Chromosomal location | QTL | Expression |
|---|---|---|---|
| Sodium channel, voltage-gated, type 2 α 1 polypeptide | chr3:47531852-47616843 | Anxiety-related QTL10 | |
| Despair-related QTL 11 | WKY/LC high | ||
| Solute carrier family 18, member 3 | chr16:7970146-7971739 | Despair-related QTL 6 | WKY/LC high |
| WKY/DR low | |||
| Glutamate receptor, metabotropic 1 | chr1:5321454-5742872 | Despair-related QTL 8 | WKY/LC high |
| Sterol-C4-methyl oxidase-like | chr16:26703604-26715501 | Despair-related, QTL 6, 7 | WKY/LC high |
| Glutathione S-transferaseA5b | chr9:20048843-20065889 | Despair-related QTL5 | WKY/LC high |
| Synaptotagmin 3b | chr1:94944917-94958568 | Climbing | WKY/LC high |
| Transferrin signal recognition | chr8:108237230-108263938 | Activity QTL 1, anxiety-related QTL 9 | WKY/LC high |
| Potassium channel, voltage-gated Kv3.2 (Kcnc2) | chr7:51347086-51505868 | Anxiety-related QTL 17, 6 | WKY/LC high |
| Inward rectifying ATP-sensitiveb | |||
| Potassium channel Kir6.2 (Kcnj11) | chr1:96693097-96695945 | Climbing | WKY/DR low |
| Synuclein γb | chr16:10025976-10030511 | Despair related, dimbing QTL6, 7 | WKY/DR low |
| Microtubule-associated protein 1A | chr3:107996094-108010036 | Despair-related QTL 2 | WKY/DR low |
| Potassium channel Kv1.1 (Kcna1) | chr4:163254845-163259290 | Anxiety-related QTL 16 | WKY/DR low |
| Sodium channel, voltage-gated | chr3:47317692-48213557 | Anxiety-related QTL 10 | |
| Type III, α polypeptide | Despair-related QTL11 | WKY/DR high | |
| Cholecystokinin | chr8:126512372-126518951 | Anxiety-related QTL 9, 15 | WKY/DR high |
| Benzodiazepine receptor | chr7:121631313-121633572 | Anxiety-related QTL 17 | |
| Stress-response QTL 8 | WKY/DR high |
The chromosomal location of genes that were detected by either SAM or cluster analysis as being differentially expressed in a strain-related manner was entered into the Rat Genome Database (RGD), Rat Genome Database Web Site, Medical College of Wisconsin, Milwaukee, WI. World Wide Web (URL:http://rgd.mcw.edu/sequenceresources/gbrowse.shtml) and QTL identified as listed (12-15-05).
The chromosomal location of genes that were detected by either SAM or cluster analysis as being differentially expressed in a strain-related manner is compared to loci identified as influencing despair (immobility) or climbing by Solberg et al (2004).