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Undifferentiated dBM-MSCs show presence of insulin (A) and C-peptide (B, E) along with glucagon (C) and somatostatin (D). F: qRT-PCR studies compare normal bone marrow and diabetic bone marrow. Freshly isolated dBM-MSCs expresses proinsulin and pancreatic transcription factor ISL1 along with the other pancreatic hormones, which are also expressed in hBM-MSCs. UD: undetected.
