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Three different views comparing the binding of MMPi 3 (left) and 5 (right) in the MMP-3 active site. Zn2+ ions are shown as magenta spheres, the MMPi in ball-and-stick colored by atom, and the protein in gray. The three views highlight the steric clash of the N-methyl group on compound 5 with the protein. Val 163 (shown as sticks in the bottom views) is the residue that conflicts with the N-methyl substituent.
