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. 2009 Dec 14;86(1):55–62. doi: 10.1093/cvr/cvp399

Figure 1.

Figure 1

C2-Cer elicited a Cl− current that resembled ICl,swell. (A) Families of currents under control conditions (Ctrl), after C2-Cer exposure (2 µM, 10 min), and after addition of DCPIB (+DCPIB; 10 μM) in continued presence of C2-Cer. Holding potential, −60 mV; test potentials, −100 to 60 mV. (B) Current–voltage (I–V) relationships for A. (C) Normalized currents at 60 mV. C2-Cer increased Cl− current by 0.70 ± 0.09 pA/pF (n = 14, P < 0.001). C2-Cer-induced current was inhibited by 76 ± 8% (n = 6, P < 0.001) by the ICl,swell-specific inhibitor DCPIB; current after DCPIB was not different than control. (D) C2-Cer-induced currents at 0.2 (n = 3), 0.36 (n = 3), 0.6 (n = 3), 2 (n = 14), and 20 μM (n = 4) and fit (solid line) to EC50 of 0.41 μM and Hill coefficient of 3.6.