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C2-H2Cer, a metabolically inactive C2-Cer analogue, did not alter membrane current, but C2-Cer elicited ICl,swell in the same cell. (A) Typical currents at 60 mV. (B) Cl− current densities in control and with C2-H2Cer and C2-Cer (both: 2 μM, 10 min). C2-H2Cer was ineffective (−4 ± 5%, n = 6, NS), whereas C2-Cer subsequently activated current in all four cells tested (P < 0.01). The data suggest C2-Cer elicited ICl,swell via its normal pathway rather than by non-specific mechanisms.
