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Tamoxifen (Tam) inhibited SMase-induced ICl,swell. (A) Currents before and after treatment with SMase (0.03 U/mL, 15−18 min) and after the addition of Tam (10 µM). (B) I–V relationships. (C) Tam fully blocks SMase-induced Cl− current (116 ± 16%, n = 5, P < 0.01).
