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. 2009 Dec 14;86(1):55–62. doi: 10.1093/cvr/cvp399

Figure 6.

Figure 6

Osmotic shrinkage partially inhibited SMase-induced ICl,swell. (A) I–V relationships before (1 T Ctrl) and after (1 T + SMase) exposure to SMase (0.03 U/mL, 18 min) in isosmotic bath solution, and then, after shrinking the same cell in hyperosmotic bath solution containing SMase (1.5 T + SMase; 0.03 U/mL, 15 min). (B) Current densities at 60 mV before and after treatment with SMase in 1 T and 1.5 T bath solutions. Cell shrinkage in 1.5 T partially inhibited the SMase-induced Cl− current (43 ± 8%, n = 6, P < 0.02). This suggested that SMase elicits ICl,swell via volume-dependent and volume-independent pathways.