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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Cell. 2010 Mar 5;140(5):744–752. doi: 10.1016/j.cell.2010.01.044

Figure 4. Physical and functional exploration of tissue-restricted heterodimers.

Figure 4

(A) Four heterodimers that display combinatorial logic across tissues. The heatmap shows the mRNA copy number of each heterodimeric TF across tissues measured by qRT-PCR (Supplementary Table 5). (B) In-vitro pull down experiment shows clear bi-directional physical interaction for each of the four heterodimers as detected originally by M2H assay (Supplementary Table 2). (C) mRNA levels of FLI1 and SMAD3 during THP-1 differentiation induced by PMA, as measured by qRT-PCR. (D) Graphical representation of FLI1/SMAD3 control during myeloid differentiation.