Table 5.
Classification of seizure parameters in inbred strains of mice after systemic administration of KA
| Seizure parameters, percentage of mice | |||||
|---|---|---|---|---|---|
| Mouse strain | Staring | Rigid posture | Repetitive movements | Rearing and falling | Duration of seizures (h) |
| BALB/cJ (n = 11) | 100 | 100 | 100 | 100 | 1.27 |
| C57BL/6J (n = 10) | 100 | 100 | 100 | 97.5 | 1.35 |
| DBA/2J (n = 10) | 100 | 100 | 100 | 100 | 2.10* |
| FVB/NJ (n = 13) | 100 | 100 | 92.3 | 98.3 | 1.42 |
| 129T2/SvEmsJ (n = 10) | 100 | 100 | 100 | 100 | 1.40 |
| SJL/J (n = 10) | 100 | 100 | 100 | 97.3 | 2.08* |
While KA induced a similar level of stage irrespective of mouse strain (F = 0.719; P = 0.621), a significant strain-dependent difference in the duration of severe seizures was observed (*P < 0.05).