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. Author manuscript; available in PMC: 2010 Mar 10.
Published in final edited form as: Clin Pharmacol Ther. 2009 Jul 1;86(5):507–510. doi: 10.1038/clpt.2009.103

Figure 1.

Figure 1

Pairwise disease correlations under the FDA-approved and practiced views. Each point represents a pairing of two of the 726 diseases in DrDKB that share at least one FDA-approved drug. Each pair of diseases was scored for similarity based on binary correlation calculated using shared FDA approved drug indications (x-axis) and combined FDA- and non-FDA drug uses (y-axis). Zero on either axis indicates no drugs in common between the two diseases, while one indicates an exactly matching set in the pair. The regression line indicates an overall similarity in FDA and combined indication data (r = 0.68, p = 2.2×10−16). However, many pairs of diseases share many FDA approved drugs, and few non-FDA drugs; we exploit these to suggest novel drug uses across the pair of diseases.