Table 3.

The predictive capacity of genetic profiling when there is a mixture of strongly predictive genes and weakly predictive genes. Odds ratios for the weakly predictive genes vary from 1.05 to 1.15 while odds ratios for the 20 strongly predictive genes vary from 1.15 to Max OR. Genes with higher odds ratios are infrequent and genes with lower odds ratios are common. The minor allele frequency of the 50 strongest genes varies from .05 to .15 and increases by .0005 after the 50^th gene. The proportion of subjects in the population who have an event is 10%. Subjects with risks exceeding 20% are classified as high risk. R²: R-squared; AUC: area under the ROC curve; TPR: true positive rate; FPR: false positive rate.

Max OR	Number of genes	Total at high risk	Cases at high risk (TPR)	Controls at high risk (FPR)	Expected Net Benefit	Net reclassification index	R2	AUC
1.5	20	0.050	0.126	0.042	0.003	0.084	0.029	0.642
	50	0.079	0.210	0.064	0.007	0.146	0.048	0.684
	150	0.129	0.394	0.099	0.017	0.295	0.108	0.767
	250	0.140	0.463	0.103	0.023	0.360	0.143	0.794
	350	0.145	0.492	0.105	0.026	0.388	0.163	0.812
2.0	20	0.106	0.312	0.082	0.013	0.229	0.080	0.723
	50	0.117	0.358	0.090	0.016	0.268	0.098	0.746
	150	0.141	0.472	0.104	0.024	0.368	0.151	0.802
	250	0.145	0.516	0.103	0.028	0.413	0.180	0.820
	350	0.148	0.539	0.104	0.031	0.436	0.198	0.834
3.0	20	0.140	0.515	0.098	0.029	0.417	0.191	0.819
	50	0.142	0.540	0.098	0.032	0.442	0.202	0.830
	150	0.150	0.590	0.101	0.036	0.489	0.241	0.856
	250	0.150	0.610	0.098	0.039	0.511	0.258	0.865
	350	0.15	0.622	0.098	0.04	0.525	0.274	0.873