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CAS proteins in apoptosis. Pro-apoptotic stimuli trigger dephosphorylation and cleavage of CAS proteins, leading to direct dominant-negative mediated focal adhesion disassembly, altering the transcriptional balance between CAS-dependent pro- and anti-survival factors. Overexpression of NEDD9 can induce cell cycle checkpoints that trigger apoptosis through additional routes. See text for details
