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. Author manuscript; available in PMC: 2011 Feb 17.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Nov 14;62(2):122–149. doi: 10.1016/j.addr.2009.10.004

Fig. 12.

Fig. 12

HPMA copolymer–9-aminocamptothecin conjugate. (A) Structure and scheme of release of unmodified 9-AC from HPMA copolymer–9-AC conjugates by a two-step process – rate controlling aromatic azo bond cleavage, followed by fast 1,6-elimination [51]; (B) survival curves of mice bearing human colon carcinoma xenografts treated by 9-AC and P-9-AC at a dose of 3 mg/kg of 9-AC or 9-AC equivalent [138].