Fig. 15.
(A) Structures of geldanamycin (GA), 17-(3-aminopropylamino)-17-demethoxy-geldanamycin (AP-GA), and P(AP-GA) (AP-GA bound to HPMA copolymer via GFLG spacers); (B) gene expression of cell stress response-related proteins in A2780 ovarian carcinoma cells treated with GA, AP-GA, and P(AP-GA) at 2×IC50 concentration for 6 or 12 h on the Atlas human 1.2 array [91].
