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. Author manuscript; available in PMC: 2011 Feb 17.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Nov 14;62(2):122–149. doi: 10.1016/j.addr.2009.10.004

Fig. 17.

Fig. 17

Structure of HPMA copolymer–prostaglandin E1-Asp8 conjugate and mechanism of its cleavage by cathepsin K followed by 1,6-elimination (A) [50]; Bone formation measured in cancellous bone from the lumbar vertebral bodies in ovariectomized rats 4 weeks after a single injection of 10 mg of the conjugate (n=8) (B) [174].