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. Author manuscript; available in PMC: 2011 Feb 17.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Nov 14;62(2):122–149. doi: 10.1016/j.addr.2009.10.004

Fig. 21.

Fig. 21

The influence of different methods of binding the OV-TL16 antibody and its Fab′ fragment to HPMA copolymer–drug (adriamycin {ADR} or meso chlorin e6 mono(N-2-aminoethylamide) {Mce6}] conjugates on the affinity of conjugates to an ovarian carcinoma OVCAR-3 cell associated antigen. Affinity constants Ka (M−1×10−8) are shown for free antibody; antibody bound via amino groups, antibody bound via oxidized saccharide units in the hinge region; and Fab′ fragment bound via thioether bonds [181].