Skip to main content
. Author manuscript; available in PMC: 2011 Feb 17.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Nov 14;62(2):122–149. doi: 10.1016/j.addr.2009.10.004

Fig. 25.

Fig. 25

Self-assembly of HPMA graft copolymers, CCK-P and CCE-P, into hybrid hydrogels mediated by antiparallel heterodimer coiled-coil formation. Two distinct pentaheptad peptides (CCE and CCK) were designed to create a dimerization motif and serve as physical crosslinkers (P is the HPMA copolymer backbone). Aqueous solutions of CCE-P or CCK-P did not form gels. In contrast, gel-like materials were formed from equimolar mixtures of CCE-P/CCK-P at low concentrations [211].