Figure 4.

This figure depicts a folding intermediate in a low energy ‘indirect’ path from A to B (unexplained notation taken from Figure 2). Clearly, every direct path from A to B must have the empty structure as an intermediate structure, hence the lowest barrier energy of a direct folding pathway must be at least 16.04 kcal/mol (in fact even larger due to nucleation energy). However the indirect folding pathway depicted in Table 3 has a barrier energy of 13.68 kcal/mol.