Scheme 1.
Synthesis of 2′-deoxy-2-N-modified guanosine. (a) TBDMSCl, imidazole, DMF, rt, 94%; (b) 12, K2CO3, rt, 55%; (c) phenoxyacethyl chloride, 1-HOBt, pyridine, CH3CN, rt, 37%; (d) 12, K2CO3, rt, 15%; (e) TBAF, THF, rt, 33%.
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