FIG. 3.

ABT-737 prevents the appearance of large conductance channel activity in mitochondrial outer membranes after a hypoxic insult to the synapse. A: examples of mitochondrial channel activity before and within 30 min of the onset of hypoxia in the absence of ABT-737 (top) and in the presence of ABT-737 (bottom). Recordings were made at +60 mV. B: group data from all mitochondrial recordings before and 30 min after the onset of hypoxia, in the absence of ABT-737 (left) and in the presence of 5 µM ABT-737 (right). [P represents probability of occurrence of channel openings with small conductance (<180 pS), intermediate conductance (180–750 pS), or large conductance (>750 pS); n = 8 recordings in each group]. There is no statistically significant difference between the probability of observing closed states in controls and in ABT-737–treated mitochondria.