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. Author manuscript; available in PMC: 2010 Mar 11.
Published in final edited form as: J Neurophysiol. 2007 Dec 26;99(3):1515–1522. doi: 10.1152/jn.00598.2007

FIG. 4.

FIG. 4

ABT-737 delays decline in synaptic responses during a hypoxic insult to the synapse. A: postsynaptic responses to a suprathreshold stimulus to the presynaptic nerve before and 20 min after the onset of hypoxia in an untreated synapse (left) and in one injected with ABT-737 (right). B: examples of the time course of the decline in slope of the postsynaptic potential in response to hypoxia. Responses of an ABT-737–injected synapse are compared with those of a control, untreated synapse. C: example of an increase in slope over time in a hypoxic synapse previously injected with ABT-737. D: combined data from all experiments comparing the half time of rundown of synaptic function in control vs. ABT-737-injected synapses (*P< 0.03, n = 11 hypoxic controls and n = 9 ABT-737–treated hypoxic synapses).

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