Table 1.

9L cell uptake of (R)- and (S)-[¹⁸F]5 and (R)- and (S)-[¹⁸F]8 at 30 minutes incubation with or without inhibitors.

		Control	BCH	MeAIB	ACS
(R)-FAMP 5	uptake	13.06±0.23	4.27±0.21	5.51±0.16	1.70±0.02
	inhibition		67.34	57.79	86.98
	p		<0.0001	<0.0001	<0.0001
(S)-FAMP 5	uptake	4.77±0.73	1.21±0.13	3.29±0.15	1.33±0.27
	inhibition		74.66	30.93	72.18
	p		<0.002	<0.03	<0.002
(R)-NMeFAMP 8	uptake	7.08±0.47	3.26±0.22	0.60±0.12	0.75±0.09
	inhibition		53.93	91.59	89.42
	p		<0.0001	<0.0001	<0.0001
(S)-NMeFAMP 8	uptake	3.87±0.22	2.76±0.20	0.82±0.11	1.62±0.08
	inhibition		28.7	78.89	58.15
	p		<0.002	<0.0001	<0.0001

Values are reported as percent uptake of the initial dose per 0.5 million cells (% ID/5×10⁵ cells) ± standard deviation (SD) (n=3).

Inhibition is expressed as percent relative to control (%).

p values represent comparisons of uptake with inhibitors to control uptake for each radiotracer using one-way ANOVA tests.