Fig. 6.
(A) The influence of Zn-templated interfacial mutations in i1 on the conformations of Cu-mediated dimeric assemblies. (B) Backbone superposition of Cu2:RIDC-12 (gray) and a dimeric half of Zn4:RIDC-14 (orange) that contains i1. Interfacial residues of Cu2:RIDC-12 are shown as sticks; see Fig. S3 for detailed comparison of Cu2:RIDC-12 and Zn4:RIDC-14 interfaces. (C) Cu coordination environment in Cu2:RIDC-12 (Site 1), highlighting the open coordination sites occupied by two water molecules. The Glu81 side chain from a crystallographic symmetry-related dimer that forms H-bonds to the coordinated water molecules is shown in light gray. The Fo-Fc omit electron density map is contoured at 3σ.