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Results of LDH assays for each of the sets of MCF-10-2A cells transfected with Precision Shuttle vectors as labeled on the abscissa for A–C. EV is empty vector; HDM-2 is overexpressed HDM-2; HDM-2 + CAAX is full-length HDM-2 with the membrane-targeting CVVK sequence on the carboxyl terminus; del1-109 HDM-2 + CAAX is HDM-2 without its p53 (PNC-27)-binding domain, residues 1-109, attached on its C terminus to the CVVK membrane-localization sequence.
