Table 2.

Association of SNP rs4054823 at 17p12 with aggressiveness of PCa

	Genotype frequency						Allele test				Genotype test
	Aggressive			Nonaggressive			Frequency (T)				Recessive		Dominant
Study populations	CC	CT	TT	CC	CT	TT	Agg.	Nonagg.	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
CGEMS study
ACS	171	467	275	152	349	183	0.56	0.52	1.15(1.00–1.32)	0.05	1.18(0.95–1.47)	0.14	1.24(0.97–1.58)	0.09
ATBC	52	119	67	124	253	132	0.53	0.51	1.10(0.88–1.37)	0.39	1.12(0.79–1.58)	0.52	1.15(0.80–1.66)	0.45
HPFS	29	43	46	75	191	123	0.57	0.56	1.04(0.78–1.40)	0.78	1.38(0.90–2.12)	0.14	0.73(0.45–1.20)	0.21
PLCO	119	332	233	104	253	126	0.58	0.52	1.28(1.08–1.51)	3.7E-03	1.46(1.13–1.89)	3.6E-03	1.30(0.97–1.75)	0.08
Sub total	371	961	621	455	1046	564	0.56	0.53	1.17(1.06–1.28)	9.8E-04	1.27(1.10–1.47)	9.1E-04	1.18(1.00–1.38)	0.04
Confirmation
CAPS	247	589	387	331	841	428	0.56	0.52	1.11(1.00–1.24)	0.04	1.27(1.08–1.49)	4.5E-03	1.03(0.86–1.24)	0.75
JHH	289	662	448	912	2152	1217	0.56	0.54	1.09(1.00–1.19)	0.05	1.19(1.04–1.35)	1.0E-02	1.04(0.90–1.21)	0.61
PROCAP	35	93	81	853	2079	1215	0.61	0.54	1.31(1.07–1.61)	0.01	1.53(1.15–2.03)	3.5E-03	1.29(0.89–1.87)	0.18
Sub total	571	1344	916	2096	5072	2860	0.56	0.54	1.12(1.05–1.19)	5.0E-04	1.25(1.13–1.37)	6.2E-06	1.06(0.95–1.18)	0.32
All populations	942	2305	1537	2551	6118	3424	0.56	0.54	1.13(1.08–1.19)	2.1E-06	1.26(1.16–1.36)	2.1E-08	1.09(1.00–1.20)	0.05

Recessive and dominant models are defined in terms of risk allele T. For Subtotal and All populations, the P value and OR (95%CI) were calculated from the CMH test. Breslow-Day P value for all populations / recessive mode is 0.5646.