Figure 10.

Intestinal transit is reduced in Gfrα1^+/− and accelerated in GFAP–Gdnf mice. The distribution of FITC-dextran along the length of the bowel was analyzed 1 h after ingestion. A, Gfrα1^+/− mice had less FITC in the distal bowel than WT mice. B, GFAP–Gdnf mice had more FITC in the distal bowel than WT mice. WT controls for each mutant mouse line were matched for strain background of the mutant, and transit is different for the two WT mouse strains analyzed. n = 4 mice of each mutant genotype and 4 matched controls.