Figure 3.

Increased GDNF influences some aspects of myenteric plexus morphogenesis. NADPH-d myenteric neuron fibers have a higher density around enteric ganglia in GFAP–Gdnf mice (E) than WT animals (A), but mice injected with GDNF (F) do not have an increase in NADPH-d-stained neuronal fibers around enteric ganglia compared with controls (B). Tryptophan hydroxylase (C, G) and acetylcholinesterase (D, H) stained myenteric plexus in WT (C, D) and GFAP–Gdnf transgenic mice (G, H) appear similar. Scale bar (in A), 100 μm.