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. Author manuscript; available in PMC: 2010 Mar 11.
Published in final edited form as: J Biol Chem. 1992 Nov 25;267(33):23903–23909.

Fig. 1. Schematic representation of site-directed mutants within the regulatory region of smooth muscle myosin light chain kinases.

Fig. 1

A, charge reversal mutants; B, mutants at residues 965, 966, and 967. The amino acid sequence within a portion of the regulatory region of rabbit smooth muscle myosin light chain kinase (Leu940 to Ser992) is shown below the sequence for smooth muscle light chain. This region contains a pseudosubstrate domain (Ser964 to Val984) and calmodulin binding domain (Ala973 to Leu990). The specific amino acid substitutions are indicated below the sequence of the regulatory region. Basic residues in the pseudosubstrate region are aligned with important substrate determinants of the light chain.