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. Author manuscript; available in PMC: 2010 Mar 11.
Published in final edited form as: Nat Neurosci. 2007 Jun 3;10(7):896–902. doi: 10.1038/nn1919

Figure 5.

Figure 5

Suppression of conditioned responses by inhibition of neurons in the CeA and DG. (a) Administration of 8-OH-DPAT (0.2 or 0.5 mg per kg, subcutaneous) to Htr1aCeA mice before ambiguous-cue fear-conditioning testing suppressed freezing to both partial and perfect cues (saline, N = 12; 0.2 mg per kg, N = 12; 0.5 mg per kg, N = 11; * P < 0.05, *** P < 0.001). Similar treatment of knockout mice was ineffective (saline, N = 11; 0.2, N = 9; 0.5, N = 11). (b) Administration of 8-OH-DPAT (0.2 or 0.5 mg per kg, subcutaneous) to Htr1aDG mice before ambiguous-cue fear-conditioning testing suppressed freezing to the partial, but not perfect, cue (saline, N = 12; 0.2 mg per kg, N = 9; 0.5 mg per kg, N = 10; * P < 0.05, ** P < 0.01). Similar treatment of knockout mice was ineffective (Saline, N = 9; 0.2 mg per kg, N = 10; 0.5 mg per kg, N = 10). Error bars, s.e.m.