FIGURE 2.

Biodistribution of ⁶⁴Cu-RGD is different in Tax⁺ and WT mice. (A) Statistically significant differences are observed between accumulation of radioactivity in tails of 6- to 12-mo-old Tax⁺ (n = 12) and WT mice (n = 15). Additionally, uptake of ⁶⁴Cu-RGD in 6- to 12-mo-old Tax⁺ mice is higher than in those older than 12 mo (P = 0.003). (B) However, statistically significant differences are not observed when radiopharmaceutical accumulation in tails of Tax⁺ mice that are older than 12 mo (n = 5) is compared with radiopharmaceutical accumulation in tails of WT mice in same age range (n = 6). (C) Positive correlation exists between accumulated tracer uptake in Tax⁺ mouse tails and measured serum TRAP levels in blood of these mice. High degree of variability reflects spontaneous nature of animal model. (D) Conversely, no correlation exists between accumulated tracer uptake in WT mouse tails and measured serum TRAP levels in blood of WT mice. Sera from both age groups were combined in parts C and D.