Table 1.

Genes of interest affected in PSD-95 knock-out mice

Gene of interest	Alternate names	Downregulation as percentage of wild type
Arcb	rg3.1	36.6
egr2 a , b	krox20; ngf1b; zfp-25; zfp-6	38.6
per1 a	rigui	42.0
Jun-B a		46.7
Nr4a1 a	N-10; gfrp; gfrp1; hbr-1; hmr; np10; tr3; nur77; tis1	50
Homer1a b , c		35.3

Six transcripts that are downregulated in PSD-95^null mice have been reported to be induced after hallucinogenic drug administration in mice. Most are immediate early genes, which is consistent with a role for PSD-95 in regulating 5-HT_2A signaling.

^a González-Maeso et al., 2003; Yuen et al., 2003.

^b Nichols and Sanders-Bush, 2002.

^cThe gene previously reported to be upregulated after hallucinogen administration is ania3, a closely related isoform that differs only in the 5′ untranslated region and a few amino acids at the C terminus.