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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2009 Jan 28;203(2):441–451. doi: 10.1007/s00213-009-1469-8

Table 1.

Site of action, doses and vehicles used for the NMDA site-selective drugs tested in rats trained to discriminate PCP or NPC 17742 from saline. NT = not tested.

Drug NMDA Receptor Site of
Action		 Doses Tested (mg/kg, i.p.) Vehicle
PCP-trained NPC17742-
Trained
PCP Channel site antagonist 0.5, 1, 2, 4, 8 NT Saline
NPC 17742 NMDA-site antagonist NT 1, 2, 4, 16 Saline1
MDL 100,458 Glycine-site antagonist 3, 10, 30, 56, 75 NT 0.1% Tween-80
MDL 100,748 Glycine-site antagonist 1, 1.7, 3 NT 0.1% Tween-80
MDL 103,371 Glycine-site antagonist 3, 10, 15.6, 30, 56 15.6, 30, 56, 100 Water2
MDL 104,472 Glycine-site antagonist 10, 15.6, 30, 56 3, 10, 15.6 Water2
MDL 105,519 Glycine-site antagonist 5.6, 10, 15.6, 30,
56, 100		 5.6, 10, 15.6, 30 0.1% Tween-80
MRZ 2/571 Glycine-site antagonist 3, 5.6, 10, 17 3, 5.6, 10, 17 Water
MRZ 2/576 Glycine-site antagonist 1, 3, 5.6, 10 3, 5.6, 10, 17 Water
ACEA-0762 Glycine-site antagonist 0.3, 1, 3 0.3, 1, 3, 5.6 DMSO
L 701,324 Glycine-site antagonist 1, 3, 5.6, 10, 17.6 1, 3, 5.6, 10 25% PEG/ DMSO3
ACPCM Glycine-site partial agonist 30, 100, 300 NT Water
(+)-HA-966 Glycine-site partial agonist 3, 10, 30, 56 NT Water
1

First solubilized in water with equimolar NaOH to a concentration of 80 mg/ml then diluted to the desired concentration in saline.

2

First combined with 2 mEq NaOH then diluted with water and titrated to neutral pH with 1 N HCl to achieve the desired concentration.

3

25% polyethylene glycol vehicle used for testing L701, 324 in PCP-trained rats; DMSO vehicle used for testing L 701,324 in NPC 17742-trained rats.