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. Author manuscript; available in PMC: 2010 Mar 11.
Published in final edited form as: Prog Biophys Mol Biol. 2009 Jan 30;98(2-3):161–170. doi: 10.1016/j.pbiomolbio.2009.01.010

Fig. 2.

Fig. 2

Schematic diagram of the coupled human atrial myocyte/fibroblast paradigm which forms the basis of this study. (A) One human atrial myocyte was coupled to one fibroblast modeled according to (MacCannell et al., 2007), and assuming a gap junctional conductance, Ggap of 0.5 nS. The total capacitance of the human atrial myocyte is 50 pF and the capacitance of the fibroblast is 6.3 pF. (B) A schematic of the fibroblast which incorporates five active membrane conductances. The voltage-gated currents are a background Na+ current, Ib,Na; two K+ currents, IK1, and IKv; the Na+–K+ pump current INaK. INP represents the novel ligand-gated transient receptor protein (TRP) channel current which is activated by natriuretic peptide. (C) The I–V curve for the natriuretic peptide-induced conductance in the fibroblast. Note, the linear relationship having a reversal potential near 0 mV.