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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Neuropharmacology. 2009 Jul 23;57(5-6):481–495. doi: 10.1016/j.neuropharm.2009.07.027

Figure 2. Summary of modified GABAergic signaling components in psychiatric disease.

Figure 2

A. Schematic of relevant GABAergic interneuron synapses onto layer III pyramidal neurons (P) in the dorsolateral prefrontal cortex (DLPFC). Distal dendrites receive GABAergic input from Somatostatin (SST) and neuropeptide Y-expressing Interneurons (NPY) (upper left). The axon initial segment (AIS) is contacted by axons originating from chandelier neurons (Ch) located in layer IV of the DLPFC (lower right). Axons of SST/NPY, P, and Ch neurons are shown in green. B. Hypothetical AIS synapse highlighting some GABAergic synaptic components implicated in schizophrenia and/or bipolar affective disorder. Black arrows indicate reported reductions or elevations in mRNA or protein expression. Red diamonds indicate genetic association with schizophrenia or bipolar disorder.