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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Neuropharmacology. 2009 Jul 18;57(5-6):551–555. doi: 10.1016/j.neuropharm.2009.07.019

Figure 2.

Figure 2

Sarcosine evokes a GlyR mediated current. (A) Currents from one neuron evoked by 3 mM sarcosine before applying strychnine, in 30 nM and 1 μM strychnine, and after washout of strychnine. (B) Mean peak 3 mM sarcosine current in the presence of varying strychnine concentrations normalized to the peak current elicited by 3 mM sarcosine alone (n = 12). Line shows the fit to a logistic equation with an IC50 of 17 nM and an N of 1.1. (C) Currents from one neuron elicited by 300 μM glycine, 10 mM sarcosine, and 10 mM sarcosine + 300 μM glycine. “Sum” trace is the arithmetic sum of the 10 mM sarcosine and 300 μM glycine currents. (D) Current elicited by 300 μM glycine before, during a 10 mM sarcosine steady-state current, and after washout of sarcosine. (E) Currents elicited by 10 mM sarcosine before, during a 300 μM steady-state glycine current, and after washout of glycine. Traces in D and E are at the same scale and are from the same neuron.