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Model for G-protein modulation of microtubule dynamics. Upon neurotransmitter stimulation, Gα-GTP internalizes by ‘coating’ caveolar/lipid raft-derived vesicles. The internalized Gα-GTP interacts with either microtubules or tubulin, and stimulates tubulin GTPase activity at the plus end of microtubules. This increases microtubule dynamic instability, and allows for neurotransmitter-dependent plasticity. Conversely, Gβγ subunits stabilize microtubules after internalizing.
