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Nelfinavir induces activation of caspase 3 and caspase 8 despite mcl-1 upregulation. IM9, Jurkat and bone marrow fibroblast cells (BMF) were treated for 24 h with 8 μg/ml nelfinavir and analyzed by Western blot analysis for the expression of caspases and apoptosis-relevant proteins. (A) and (B): cell lysates of IM9 and Jurkat cells; (C) cell lysates of IM9 and BMF.
