Figure 12.

Variation of doublet NN values for 9 sets of parameters. Free energy values corresponding to nine sets (our set and 8 others) of thermodynamic nearest-neighbour doublet parameters at 37°C are displayed in this plot. Four (Gotoh, Vologodskii, Blake and Benight) out of the eight publicly available sets of doublet parameters correspond to models that do not account for initiation penalties for duplex formations [18], and the sodium concentration for their experiments was between 0.0195 M and 0.195 M. For the other 4 sets (Breslauer, SantaLucia, Sugimoto and Unified) the sodium concentration equals 1 M.