Table 2.
Summary of results for free energy measurements obtained with EVAL-SS methods.
| Method | Stats | MFE_AD [kcal/mol] | Pearson coeff. (r) | SSSI | Sens. | PPV | F-measure | |
|---|---|---|---|---|---|---|---|---|
| MultiRNAFold | min | 0.000 | 0.7565 | 4.35 | 40.00 | 0.1667 | 1 | 0.2857 |
| (Mathews) | q1 | 0.340 | 100.00 | 1.0000 | 1 | 1.0000 | ||
| median | 0.860 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| mean | 2.681 | 95.83 | 0.9547 | 1 | 0.9711 | |||
| q3 | 3.590 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| max | 18.400 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| stddev | 3.429 | 10.56 | 0.1224 | 0 | 0.09236 | |||
| MultiRNAFold | min | 0.000 | 0.7663 | 4.131 | 40.00 | 0.1667 | 1 | 0.2857 |
| (SantaLucia) | q1 | 0.330 | 100.00 | 1.0000 | 1 | 1.0000 | ||
| median | 0.720 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| mean | 2.528 | 96.44 | 0.9608 | 1 | 0.9747 | |||
| q3 | 3.510 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| max | 17.200 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| stddev | 3.269 | 10.23 | 0.1189 | 0 | 0.08966 | |||
| min | 0.000 | 0.7660 | 3.992 | 40.00 | 0.1667 | 1 | 0.2857 | |
| q1 | 0.256 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| median | 0.630 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| UNAFold | mean | 2.374 | 96.08 | 0.9571 | 1 | 0.9724 | ||
| q3 | 3.016 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| max | 11.880 | 100.00 | 1.0000 | 1 | 1.0000 | |||
| stddev | 3.212 | 10.66 | 0.1231 | 0 | 0.09234 | |||
| Vienna | min | 0.010 | 0.7630 | 3.667 | 5.882 | 0.0000 | 0.0000 | 0.0000 |
| Package | q1 | 1.700 | 100.000 | 1.0000 | 1.0000 | 1.0000 | ||
| median | 2.330 | 100.000 | 1.0000 | 1.0000 | 1.0000 | |||
| mean | 3.025 | 95.210 | 0.9467 | 0.9856 | 0.9616 | |||
| q3 | 3.935 | 100.000 | 1.0000 | 1.0000 | 1.0000 | |||
| max | 15.400 | 100.000 | 1.0000 | 1.0000 | 1.0000 | |||
| stddev | 2.075 | 13.74 | 0.1581 | 0.1192 | 0.1387 |
Summary of results for free energy measurements obtained with EVAL-SS methods. The p-values for the Pearson correlation test were less than 2.2e-16 in all cases.