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. 2005 Nov 15;3(4):171–178. doi: 10.1186/1897-4287-3-4-171

Figure 2.

Figure 2

Functional domains of the VHL protein and distribution of germline mutations (from VHL database) [22]. Hotspots for mutations are readily visible at amino acids 67-117, hypoxia-inducible factor (HIF)-1α binding domain (in the β-domain) and 157-170, Elongin C (EloC) binding domain (in the α-domain). Copyright 2003, The Endocrine Society [16]